An association study between the Cys311 variant of dopamine D2 receptor gene and schizophrenia in the Okinawan population

被引：20

作者：

Kaneshima, M

Higa, T

Nakamoto, H

Nagamine, M

机构：

[1] Univ Ryukyus, Fac Med, Dept Neuropsychiat, Okinawa 90301, Japan

[2] Univ Ryukyus, Ctr Gene Res, Okinawa 90301, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 1997年 / 51卷 / 06期

关键词：

association study; dopamine D-2 receptor; Okinawa; schizophrenia;

D O I：

10.1111/j.1440-1819.1997.tb02603.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuroleptic drugs have a high affinity for the dopamine D-2 receptor (DRD2); therefore DRD2 is thought to be a candidate gene for schizophrenia. Arinami et al. have reported a positive association between schizophrenia and the Cys311 variant of the DRD2 gene. We determined the allele frequency of this polymorphism in 78 Okinawan schizophrenic patients and 112 control subjects. The patients and controls did not differ significantly in allele frequencies of Cys311.

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收藏

页码：379 / 381

页数：3

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