Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

被引：1034

作者：

Dai, Yunlu ^{[1
,2
]}

Xu, Can ^{[2
]}

Sun, Xiaolian ^{[1
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Ctr Mol Imaging & Translat Med, Xiangan South Rd, Xiamen 361102, Peoples R China

[2] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2017年 / 46卷 / 12期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

MESOPOROUS SILICA NANOPARTICLES; INTERSTITIAL FLUID PRESSURE; ENDOTHELIAL GROWTH-FACTOR; TARGETED DRUG-DELIVERY; CANCER-ASSOCIATED FIBROBLASTS; NEAR-INFRARED LIGHT; KILLER T-CELLS; BREAST-CANCER; PHOTODYNAMIC THERAPY; EXTRACELLULAR-MATRIX;

D O I：

10.1039/c6cs00592f

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells, including tumour cells, macrophages, immune and fibroblast cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with a special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in detail. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic.

引用

页码：3830 / 3852

页数：23

共 290 条

[1]

VEGF-targeted magnetic nanoparticles for MRI visualization of brain tumor [J].