HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies

被引：86

作者：

de Taeye, Steven W. ^{[1
]}

Moore, John P. ^{[2
]}

Sanders, Rogier W. ^{[1
,2
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands

[2] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA

来源：

TRENDS IN IMMUNOLOGY | 2016年 / 37卷 / 03期

基金：

欧洲研究理事会; 美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; PROXIMAL EXTERNAL-REGION; B-CELL RECEPTORS; GLYCOPROTEIN TRIMERS; DEPENDENT EPITOPE; BINDING-SITE; CONFORMATIONAL EPITOPE; AFFINITY MATURATION; CRYSTAL-STRUCTURE; IMMUNOGEN DESIGN;

D O I：

10.1016/j.it.2016.01.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The identification of multiple broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) trimer has facilitated its structural characterization and guided Env immunogen design. Several recent studies constitute progress in utilizing this knowledge for the development of an HIV-1 vaccine that induces bNAbs. Native-like Env trimers can induce autologous NAb responses against resistant (Tier-2) viruses in several animal models. Here we review recent studies aimed at addressing the challenge of driving the strong but narrowly focused NAb responses to Env trimers towards ones with much greater breadth. Among strategies that merit pursuing are using multiple trimers as sequential or simultaneous immunogens, targeting the germline precursors of bNAbs, delivering sequential lineages of trimers derived from infected individuals who developed bNAbs, and presenting trimers as particulate antigens.

引用

页码：221 / 232

页数：12

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