Immunogenicity of hepatitis B vaccine in term and preterm infants

被引:30
作者
Belloni, C
Chirico, G
Pistorio, A
Orsolini, P
Tinelli, C
Rondini, G
机构
[1] IRCCS, Policlin San Matteo, Div Neonatal Intens Care, Biometr Unit, Pavia, Italy
[2] IRCCS, Policlin San Matteo, Dept Infect Dis, Pavia, Italy
关键词
hepatitis B vaccination; immune response; newborn; preterm infant;
D O I
10.1080/08035259850157426
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Some studies have suggested that decreased seroconversion rates might be found in premature infants with low birthweight (< 2000 g) following administration of hepatitis B vaccine at birth. The aim of the present investigation was to evaluate possible differences in seropositive rates between full-term and preterm infants after primary vaccination, in particular when gestational age of birthweight is very low. Two-thousand and nine neonates born to HBsAg-negative mothers were vaccinated with 10 mu g of recombinant hepatitis B virus (HBV) vaccine, from May 1991 to October 1994. Children with infections, congenital malformations or serious illnesses were excluded. HBV vaccine was administered intramuscularly, on the fourth day of life and again at 1 and 6 months of age. A 1-ml blood sample was drawn from each infant 1 month after the third vaccine dose for determination of the level of anti-HBs antibody. The response to HBV vaccination was evaluated in 241 preterm (gestational age <38 weeks) infants and 1727 term neonates. No statistical difference was observed in the distribution of anti-HBs antibody level, either between preterm infants (<38 weeks) and newborns of normal gestational age, or between low birthweight (<2500 g) and normal weight infants. The results suggest that preterm and low birthweight infants (<2500 g) respond to HBV vaccine in the same measure as normal-term infants.
引用
收藏
页码:336 / 338
页数:3
相关论文
共 12 条
[1]  
*AM AC PED, 1994, 23 AM AC PED COMM IN
[2]  
BELLONI C, 1993, MICROBIOLOGICA, V16, P237
[3]   Immune response to hepatitis B virus vaccine in 1-year-old preterm and term infants [J].
Belson, A ;
Reif, S ;
Peled, Y ;
Bujanover, Y .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1996, 23 (03) :252-255
[4]  
CHIRICO G, 1993, PEDIATRICS, V92, P717
[5]   HEPATITIS-B VACCINATION AND PRETERM INFANTS [J].
DELCANHO, R ;
GROSHEIDE, PM ;
GERARDS, LJ ;
HEIJTINK, RA ;
SCHALM, SW .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1993, 12 (05) :407-408
[6]  
GERLICH WH, 1993, HEPATITIS B VACCINES, P41
[7]   SUCCESSFUL POSTEXPOSURE VACCINATION AGAINST HEPATITIS-B IN CHIMPANZEES [J].
IWARSON, S ;
WAHL, M ;
RUTTIMANN, E ;
SNOY, P ;
SETO, B ;
GERETY, RJ .
JOURNAL OF MEDICAL VIROLOGY, 1988, 25 (04) :433-439
[8]   Immunogenicity of hepatitis B vaccine in preterm infants [J].
Kim, SC ;
Chung, EK ;
Hodina, RL ;
DeMaio, J ;
West, DJ ;
Jawad, AF ;
Watson, B .
PEDIATRICS, 1997, 99 (04) :534-536
[9]   RESPONSE OF PRETERM INFANTS TO HEPATITIS-B VACCINE [J].
LAU, YL ;
TAM, AYC ;
NG, KW ;
TSOI, NS ;
LAM, B ;
LAM, P ;
YEUNG, CY .
JOURNAL OF PEDIATRICS, 1992, 121 (06) :962-965
[10]   HEPATITIS-B VACCINATION IN PRETERM INFANTS [J].
LAU, YL .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1994, 13 (03) :243-243