Molecular basis of voltage gating of OmpF porin

被引：42

作者：

Robertson, KM ^{[1
]}

Tieleman, DP ^{[1
]}

机构：

[1] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada

来源：

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 2002年 / 80卷 / 05期

关键词：

beta-barrels; eyelet region; porins; E; coli; alpha-haemolysin;

D O I：

10.1139/O02-145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

OmpF and PhoE from Escherichia coli and related homologous proteins from other Gram-negative bacteria allow the passive transport of small polar molecules across the bacterial outer membrane. In vitro, they exhibit voltage gating depending on the experimental conditions. We review current hypotheses on the underlying molecular mechanism of voltage gating of OmpF porin and show how computer simulations can be used to examine each of the proposed mechanisms.

引用

页码：517 / 523

页数：7

共 45 条

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