Striatal gray matter loss in Huntington's disease is leftward biased

被引：51

作者：

Muehlau, Mark

Gaser, Christian

Wohlschlaeger, Afra M.

Weindl, Adolf

Staedtler, Michael

Valet, Michael

Zimmer, Claus

Kassubek, Jan

Peinemann, Alexander

机构：

[1] Tech Univ Munich, Dept Neurol, D-81675 Munich, Germany

[2] Univ Jena, Dept Psychiat, D-6900 Jena, Germany

[3] Tech Univ Munich, Dept Neuroradiol, D-8000 Munich, Germany

[4] Tech Univ Munich, Dept Nucl Med, D-8000 Munich, Germany

[5] Univ Ulm, Dept Neurol, D-7900 Ulm, Germany

来源：

MOVEMENT DISORDERS | 2007年 / 22卷 / 08期

关键词：

gray matter loss; Huntington's disease; lateralization; striatum; voxel-based morphometry;

D O I：

10.1002/mds.21137

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indiation of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD. (c) 2007 Movement Disorder Society.

引用

页码：1169 / 1173

页数：5

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