Epithelial-mesenchymal transition in cancer development and its clinical significance

被引：650

作者：

Iwatsuki, Masaaki ^{[1
,2
]}

Mimori, Koshi ^{[1
]}

Yokobori, Takehiko ^{[1
]}

Ishi, Hideshi ^{[1
,3
]}

Beppu, Toru ^{[2
]}

Nakamori, Shoji ^{[4
]}

Baba, Hideo ^{[2
]}

Mori, Masaki ^{[1
,3
]}

机构：

[1] Kyushu Univ, Med Inst Bioregulat, Dept Surg Oncol, Beppu, Oita, Japan

[2] Kumamoto Univ, Grad Sch Med Sci, Dept Surg Gastroenterol, Kumamoto, Japan

[3] Osaka Univ, Grad Sch Med, Dept Surg Gastroenterol, Osaka, Japan

[4] Osaka Natl Hosp, Dept Surg, Osaka, Japan

来源：

CANCER SCIENCE | 2010年 / 101卷 / 02期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

SQUAMOUS-CELL CARCINOMA; E-CADHERIN EXPRESSION; FACTOR RECEPTOR INHIBITION; TRANSCRIPTION FACTOR SNAIL; INVASION-SUPPRESSOR GENE; SMALL-MOLECULE INHIBITOR; BETA-CATENIN EXPRESSION; BREAST-CANCER; COLORECTAL-CANCER; STEM-CELLS;

D O I：

10.1111/j.1349-7006.2009.01419.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epithelial-mesenchymal transition (EMT) plays a critical role in embryonic development. EMT is also involved in cancer progression and metastasis and it is probable that a common molecular mechanism is shared by these processes. Cancer cells undergoing EMT can acquire invasive properties and enter the surrounding stroma, resulting in the creation of a favorable microenvironment for cancer progression and metastasis. Furthermore, the acquisition of EMT features has been associated with chemoresistance which could give rise to recurrence and metastasis after standard chemotherapeutic treatment. Thus, EMT could be closely involved in carcinogenesis, invasion, metastasis, recurrence, and chemoresistance. Research into EMT and its role in cancer pathogenesis has progressed rapidly and it is now hypothesized that novel concepts such as cancer stem cells and microRNA could be involved in EMT. However, the involvement of EMT varies greatly among cancer types, and much remains to be learned. In this review, we present recent findings regarding the involvement of EMT in cancer progression and metastasis and provide a perspective from clinical and translational viewpoints. (Cancer Sci 2010; 101: 293-299)

引用

页码：293 / 299

页数：7

共 109 条

[1] miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy [J].