Flushing bacteria out of the bladder

被引:7
作者
Eto, Danelle S. [1 ]
Mulvey, Matthew A. [1 ]
机构
[1] Univ Utah, Div Cell Biol & Immunol, Dept Pathol, Salt Lake City, UT 84112 USA
关键词
D O I
10.1038/nm0507-531
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A drug that elevates host cAMP levels forces pathogenic bacteria out of bladder epithelial cells. This process may make urinary tract infections more amenable to treatment with antibiotics (pages 625-630).
引用
收藏
页码:531 / 532
页数:2
相关论文
共 13 条
[1]   The Trypanosoma cruzi-host-cell interplay:: location, invasion, retention [J].
Andrade, LO ;
Andrews, NW .
NATURE REVIEWS MICROBIOLOGY, 2005, 3 (10) :819-823
[2]   The uroepithelium: Not just a passive barrier [J].
Apodaca, G .
TRAFFIC, 2004, 5 (03) :117-128
[3]   Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells [J].
Bishop, Brian L. ;
Duncan, Mathew J. ;
Song, Jeongmin ;
Li, Guojie ;
Zaas, David ;
Abraham, Soman N. .
NATURE MEDICINE, 2007, 13 (05) :625-630
[4]   Covert operations of uropathogenic Escherichia coli within the urinary tract [J].
Bower, JM ;
Eto, DS ;
Mulvey, MA .
TRAFFIC, 2005, 6 (01) :18-31
[5]   Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes [J].
Chen, YR ;
Guo, XM ;
Deng, FM ;
Liang, FX ;
Sun, WY ;
Ren, MD ;
Izumi, T ;
Sabatini, DD ;
Sun, TT ;
Kreibich, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) :14012-14017
[6]   Actin-gated intracellular growth and resurgence of uropathogenic Escherichia coli [J].
Eto, DS ;
Sundsbak, JL ;
Mulvey, MA .
CELLULAR MICROBIOLOGY, 2006, 8 (04) :704-717
[7]  
Foxman B, 2002, AM J MED, V113, p5S
[8]   Defective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells [J].
Huynh, C ;
Roth, D ;
Ward, DM ;
Kaplan, J ;
Andrews, NW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (48) :16795-16800
[9]   Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis [J].
Justice, SS ;
Hung, C ;
Theriot, JA ;
Fletcher, DA ;
Anderson, GG ;
Footer, MJ ;
Hultgren, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (05) :1333-1338
[10]   Type 1 pilus-mediated bacterial invasion of bladder epithelial cells [J].
Martinez, JJ ;
Mulvey, MA ;
Schilling, JD ;
Pinkner, JS ;
Hultgren, SJ .
EMBO JOURNAL, 2000, 19 (12) :2803-2812