2-arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice

被引：131

作者：

Gallily, R

Breuer, A

Mechoulam, R

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 406卷 / 01期

基金：

以色列科学基金会;

关键词：

endocannabinoid; radical oxygen intermediate; cytokine;

D O I：

10.1016/S0014-2999(00)00653-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

2-Arachidonylglycerol (2-AG) inhibits the production in Vitro of tumor necrosis factor-alpha (TNF-alpha) by mouse macrophages, as well as in mice. It has no effect on the production of nitric oxide (NO). The effect on TNF-alpha is enhanced when 2-AG is administered together with 2-linoleylglycerol (2-Lino-G) and 2-palmitylglycerol (2-PalmG), an 'entourage effect' previously noted in several behavioral and binding assays. 2-AG also suppresses the formation of radical oxygen intermediates. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：R5 / R7

页数：3

共 8 条

[1] MYCOPLASMA STIMULATES THE PRODUCTION OF OXIDATIVE RADICALS BY MURINE PERITONEAL-MACROPHAGES [J].