Maternal neuronal antibodies associated with autism and a language disorder

被引:157
作者
Dalton, P
Deacon, R
Blamire, A
Pike, M
McKinlay, I
Stein, J
Styles, P
Vincent, A
机构
[1] Univ Oxford, Dept Clin Neurol, Neurosci Grp, Oxford, England
[2] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England
[3] Univ Oxford, MRC, Biochem & Clin Magnet Resonance Unit, Dept Biochem, Oxford, England
[4] Univ Oxford, Dept Paediat, Oxford, England
[5] Mackay Gordon Ctr, Manchester, Lancs, England
[6] Univ Oxford, Dept Physiol, Oxford, England
关键词
D O I
10.1002/ana.10557
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neurodevelopmental disorders could be caused by maternal antibodies or other serum factors. We detected serum antibodies binding to rodent Purkinje cells and other neurons in a mother of three children: the first normal, the second with autism, and the third with a severe specific language disorder. We injected the serum (0.5-1.0ml/day) into pregnant mice during gestation and found altered exploration and motor coordination and changes in cerebellar magnetic resonance spectroscopy in the mouse offspring, comparing with offspring of mice injected with sera from mothers of healthy children. This evidence supports a role for maternal antibodies in some forms of neurodevelopmental disorder.
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页码:533 / 537
页数:5
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