Prion genetics: New rules for a new kind of gene

被引：61

作者：

Wickner, RB ^{[1
]}

Edskes, HK ^{[1
]}

Ross, ED ^{[1
]}

Pierce, MM ^{[1
]}

Baxa, U ^{[1
]}

Brachmann, A ^{[1
]}

Shewmaker, F ^{[1
]}

机构：

[1] NIDDKD, NIH, Lab Biochem & Genet, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF GENETICS | 2004年 / 38卷

关键词：

amyloid; URE3; PSI; Het-s; PIN; PrP;

D O I：

10.1146/annurev.genet.38.072902.092200

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Just as nucleic acids can carry out enzymatic reactions, proteins can be genes. These heritable infectious proteins (prions) follow unique genetic rules that enable their identification: reversible curing, inducible "spontaneous generation," and phenotype surprises. Most prions are based on self-propagating amyloids, depend heavily on chaperones, show strain phenomena and, like other infectious elements, show species barriers to transmission. A recently identified prion is based on obligatory self-activation of an enzyme in trans. Although prions can be detrimental, they may also be beneficial to their hosts.

引用

页码：681 / 707

页数：31

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