HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice

被引：32

作者：

Bertaux, F

Sharp, AH

Ross, CA

Lehrach, H

Bates, GP

Wanker, E

机构：

[1] United Med & Dent Sch Guys & St Thomas Hosp, Guys Hosp, Div Med & Mol Genet, London SE1 9RT, England

[2] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[4] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

FEBS LETTERS | 1998年 / 426卷 / 02期

基金：

英国惠康基金;

关键词：

Huntington's disease; triplet repeat; polyglutamine; HAP1;

D O I：

10.1016/S0014-5793(98)00352-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HAP1 (huntingtin associated protein) has previously been found to interact with huntingtin (htt) in a glutamine length dependent manner and has been proposed to play a role in the cell specific neurodegeneration observed in Huntington's disease (HD), We have isolated mouse HAP1 (hap1) and have shown that expression is not enriched in areas specifically affected in HD, We hale used the yeast two hybrid system to demonstrate that htt amino acids 171-230 are necessary for the hap1-htt binding and that hap1 does not interact with the transgene exon 1 protein in a transgenic model of HD. (C) 1998 Federation of European Biochemical Societies.

引用

页码：229 / 232

页数：4

共 24 条

[1] [Anonymous], [No title captured]
[2] [Anonymous], NEUROBIOL DIS
[3] Fast transport and retrograde movement of huntingtin and HAP 1 in axons
BlockGalarza, J
Chase, KO
Sapp, E
Vaughn, KT
Vallee, RB
DiFiglia, M
Aronin, N
[J]. NEUROREPORT, 1997, 8 (9-10) : 2247 - 2251
[4] Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rad guanine nucleotide exchange factor domain
Colomer, V
Engelender, S
Sharp, AH
Duan, K
Cooper, JK
Lanahan, A
Lyford, G
Worley, P
Ross, CA
[J]. HUMAN MOLECULAR GENETICS, 1997, 6 (09) : 1519 - 1525
[5] Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion
David, G
Abbas, N
Stevanin, G
Durr, A
Yvert, G
Cancel, G
Weber, C
Imbert, G
Saudou, F
Antoniou, E
Drabkin, H
Gemmill, R
Giunti, P
Benomar, A
Wood, N
Ruberg, M
Agid, Y
Mandel, JL
Brice, A
[J]. NATURE GENETICS, 1997, 17 (01) : 65 - 70
[6] Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
Davies, SW
Turmaine, M
Cozens, BA
DiFiglia, M
Sharp, AH
Ross, CA
Scherzinger, E
Wanker, EE
Mangiarini, L
Bates, GP
[J]. CELL, 1997, 90 (03) : 537 - 548
[7] Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
DiFiglia, M
Sapp, E
Chase, KO
Davies, SW
Bates, GP
Vonsattel, JP
Aronin, N
[J]. SCIENCE, 1997, 277 (5334) : 1990 - 1993
[8] HUNTINGTIN IS A CYTOPLASMIC PROTEIN ASSOCIATED WITH VESICLES IN HUMAN AND RAT-BRAIN NEURONS
DIFIGLIA, M
SAPP, E
CHASE, K
SCHWARZ, C
MELONI, A
YOUNG, C
MARTIN, E
VONSATTEL, JP
CARRAWAY, R
REEVES, SA
BOYCE, FM
ARONIN, N
[J]. NEURON, 1995, 14 (05) : 1075 - 1081
[9] Huntingtin-associated protein 1 (HAP1) interacts with the p150(Glued) subunit of dynactin
Engelender, S
Sharp, AH
Colomer, V
Tokito, MK
Lanahan, A
Worley, P
Holzbaur, ELF
Ross, CA
[J]. HUMAN MOLECULAR GENETICS, 1997, 6 (13) : 2205 - 2212
[10] FROHMAN MA, 1994, PCR METH APPL, V4, pS40

← 1 2 3 →