Of mice and men: hybridoma and recombinant antibodies

被引：89

作者：

Little, M

Kipriyanov, SM

Le Gall, F

Moldenhauer, G

机构：

[1] Affirmed Therapeut AG, D-68526 Ladenburg, Germany

[2] German Canc Res Ctr, D-69120 Heidelberg, Germany

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 08期

关键词：

D O I：

10.1016/S0167-5699(00)01668-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thousands of mouse monoclonal antibodies have been produced from hybridomas over the past 25 years. The same technique can now be used to clone human antibodies from transgenic mice. Full-length antibodies and recombinant fragments engineered for various diagnostic and therapeutic applications can be obtained in reasonably large amounts after expression in mammalian cells, milk and plants.

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收藏

页码：364 / 370

页数：7

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