Direct synthesis of heteroarylethynes via palladium-catalyzed coupling of heteroaryl halides with ethynylzinc halides. Its application to an efficient synthesis of a thiophenelactone from Chamaemelum nobile L

被引：30

作者：

Negishi, E ^{[1
]}

Xu, CD ^{[1
]}

Tan, Z ^{[1
]}

Kotora, M ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

HETEROCYCLES | 1997年 / 46卷

关键词：

D O I：

10.3987/COM-97-S79

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of terminal alkynes containing a heteroaryl group can be directly and selectively synthesized by the Pd-catalyzed coupling of heteroaryl iodides or bromides with ethynylzinc halides. Various compounds of this class containing furan, thiophene, and pyridine have been prepared, and the procedure has been applied to an efficient and selective synthesis of a thiophenelactone from Chamaemelum nobile L.

引用

页码：209 / 214

页数：6

共 14 条

[1]

AMES DE, 1981, SYNTHESIS-STUTTGART, P364

[2] SYNTHESIS OF 3,2'-5',3'-TERTHIOPHENE AND OTHER TERTHIOPHENES BY THE THIOPHENECARBOXALDEHYDE-]ETHYNYLTHIOPHENE-]DITHIENYLBUTADIYNE ROUTE [J].