Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease

被引：24

作者：

Dhaenens, CM

Van Brussel, E

Schraen-Maschke, S

Pasquier, F

Delacourte, A

Sablonnière, B

机构：

[1] Univ Lille 2, INSERM U422, Lab G Biserte, Grp Vieillissement Cerebral & Malad Neurodegenera, F-59045 Lille, France

[2] Univ Lille 2, Fac Med, F-59045 Lille, France

[3] Ctr Hosp Reg & Univ Lille, Hop R Salengro, Clin Neurol & Ctr Memoire, F-59037 Lille, France

来源：

NEUROSCIENCE LETTERS | 2004年 / 368卷 / 03期

关键词：

Alzheimer's disease; single nucleotide polymorphisms; kinesin light-chain gene; case-control study;

D O I：

10.1016/j.neulet.2004.07.040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The transport of amyloid precursor protein is mediated through its interaction with kinesin light-chain 1 (KNS2). We hypothesized that kinesin light-chain dysfunction might be involved in the pathogenesis of Alzheimer's disease (AD). To assess the physiological relevance of an allelic variation in the KNS2 gene, the association analysis of three single nucleotide polymorphisms (SNPs) in the 5'UTR or in intronic sequences of KNS2 gene were performed in 100 AD brain patients and in 103 controls. For one of these polymorphisms (G58836C in intron 13), the association between AD and the C allele was found to be significant (odds ratio = 1.73, 95% CI: 1.12-2.67, P = 0.012). No synergistic effects were found between the APOE epsilon4 allele and KNS2 gene polymorphisms. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：290 / 292

页数：3

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