Differential production of chemokines by phagocytosing rat neutrophils and macrophages

被引：8

作者：

Al-Mokdad, M ^{[1
]}

Shibata, F ^{[1
]}

Takano, K ^{[1
]}

Nakagawa, H ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol Chem, Sugitani, Toyama 93001, Japan

来源：

INFLAMMATION | 1998年 / 22卷 / 02期

关键词：

D O I：

10.1023/A:1022383922039

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this study, rat neutrophils and macrophages produced cytokine-induced neutrophil chemoattractants (CINCs) and rat macrophage inflammatory protein-1 alpha (MIP-1 alpha) in different patterns during phagocytosis of heat-killed yeast cells in vitro. The cultured supernatants of the phagocytosing rat neutrophils and macrophages had chemotactic activities toward neutrophils, and the chemotactic potencies were markedly inhibited by anti-CINCs IgGs or/and anti-MIP-1 alpha IgG, suggesting that CINCs and MIP-1 alpha are major neutrophil chemoattractants produced by the phagocytosing neutrophils and macrophages. Dexamethasone suppressed the production of CINCs and MIP-1 alpha by the phagocytosing cells in a dose-dependent manner. Our results demonstrate significant differences in the production of CINCs and MIP-1 alpha by neutrophils and macrophages during phagocytosis of yeast cells and thus may suggest the different contribution of each chemokine to neutrophil recruitment in the processes of inflammation in rats.

引用

页码：145 / 159

页数：15

共 35 条

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[2]

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[3]

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[4]

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