Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells

被引：31

作者：

Ishigatsubo, Yoshiaki ^{[1
]}

Ihata, Atsushi ^{[1
]}

Kobayashi, Hiroshi ^{[1
]}

Hama, Maasa ^{[1
]}

Kirino, Yohei ^{[1
]}

Ueda, Atsuhisa ^{[1
]}

Takeno, Mitsuhiro ^{[1
]}

Shirai, Akira ^{[2
]}

Ohno, Shigeru ^{[3
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Internal Med & Clin Immunol, Kanazawa Ku, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Coll Nursing, Yokohama, Kanagawa 232, Japan

[3] Yokohama City Univ, Med Ctr, Ctr Rheumat Dis, Yokohama, Kanagawa 232, Japan

来源：

MODERN RHEUMATOLOGY | 2010年 / 20卷 / 03期

关键词：

Systemic sclerosis; Angiogenesis; Bone-marrow-derived cells; Autologous transplantation; Intractable ulcer; ENDOTHELIAL PROGENITOR CELLS; MONONUCLEAR-CELLS; GROWTH-FACTOR; VASCULOGENESIS; ISCHEMIA; DISEASE;

D O I：

10.1007/s10165-010-0274-x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

We examined the efficacy and safety of autologous transplantation of bone-marrow-derived cells in patients with intractable ulcers caused by systemic sclerosis. Eight patients with ulcers resistant to treatment were enrolled. Bone marrow cells were gathered from the bilateral iliac crests with multiple repositioning bone marrow needles, and bone-marrow-derived mononuclear cells were isolated and injected into skeletal muscles of the ischemic limb. Visual analog scale (VAS), Sclerosis Health Assessment Questionnaire (SHAQ), modified Rodnan total skin score (mTSS), and the size and depth of the ulcer were examined. Thermography, capillaroscopy, intra-arterial digital subtraction angiography (IA-DSA), and laser Doppler flowmetry were also examined before and after transplantation. In all patients, reduction of ulcer size and improvement of VAS were observed after treatment. Elevation of surface temperature, increase of blood flow volume, and new capillaries of the nail bed were also found after our treatment. There were no major adverse effects of this treatment. Autologous transplantation of bone-marrow-derived cells was shown to be a novel and useful approach to intractable ulcers in systemic sclerosis.

引用

页码：263 / 272

页数：10

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