Moderation of the platelet releasate response by aspirin

被引：98

作者：

Coppinger, Judith A.

O'Connor, Roisin

Wynne, Kieran

Flanagan, Michelle

Sullivan, Matthew

Maguire, Patricia B.

Fitzgerald, Desmond J.

Cagney, Gerard ^{[1
]}

机构：

[1] Univ Coll Dublin, Conway Inst, Sch Biomol & Biomed Sci, Dublin 4, Ireland

[2] Scripps Res Inst, Dept Cell Biol, La Jolla, CA USA

[3] Univ Coll Dublin, Sch Med & Med Sci, Dublin 4, Ireland

[4] Univ Coll Dublin, Conway Inst, Proteome Res Ctr, Dublin 4, Ireland

来源：

BLOOD | 2007年 / 109卷 / 11期

关键词：

D O I：

10.1182/blood-2006-07-038539

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.

引用

收藏

页码：4786 / 4792

页数：7

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