CR377, a new pentaketide antifungal agent isolated from an endophytic fungus

被引：64

作者：

Brady, SF ^{[1
]}

Clardy, J ^{[1
]}

机构：

[1] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 10期

关键词：

D O I：

10.1021/np990568p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antifungal activity. CR377, a new pentaketide antifungal agent, was isolated from the culture broth of a fungus, CR377 (Fusarium sp.), that showed potent activity against Candida albicans in this assay. The structure of CR377 was established using 1- and 2-D NMR and HRFABMS.

引用

页码：1447 / 1448

页数：2

共 16 条

[1] DISCOVERY, BIOSYNTHESIS, AND MECHANISM OF ACTION OF THE ZARAGOZIC ACIDS - POTENT INHIBITORS OF SQUALENE SYNTHASE [J].

BERGSTROM, JD ;

DUFRESNE, C ;

BILLS, GF ;

NALLINOMSTEAD, M ;

BYRNE, K .

ANNUAL REVIEW OF MICROBIOLOGY, 1995, 49 :607-639

[2]

BOSSCHE HV, 1997, REV IBEROAM MICOL, V14, P44

[3] ALTERNARIC ACID, A BIOLOGICALLY ACTIVE METABOLIC PRODUCT OF THE FUNGUS ALTERNARIA-SOLANI [J].

BRIAN, PW ;

CURTIS, PJ ;

HEMMING, HG ;

UNWIN, CH ;

WRIGHT, JM .

NATURE, 1949, 164 (4169) :534-534

[4]

Dreyfuss M.M., 1994, DISCOVERY NATURAL PR

[5] THE FUNGAL DIMENSION OF BIODIVERSITY - MAGNITUDE, SIGNIFICANCE, AND CONSERVATION [J].

HAWKSWORTH, DL .

MYCOLOGICAL RESEARCH, 1991, 95 :641-655

[6]

Henkel T, 1999, ANGEW CHEM INT EDIT, V38, P643, DOI 10.1002/(SICI)1521-3773(19990301)38:5<643::AID-ANIE643>3.0.CO

[7]

2-G

[8]

KLEIN E, 1969, Tetrahedron Letters, V27, P2279

[9] STUDIES ON PODOBLASTIN .1. PODOBLASTIN-A, PODOBLASTIN-B AND PODOBLASTIN-C - NEW ANTIFUNGAL 3-ACYL-4-HYDROXY-5,6-DIHYDRO-2-PYRONES OBTAINED FROM PODOPHYLLUM-PELTATUM L [J].

MIYAKADO, M ;

INOUE, S ;

TANABE, Y ;

WATANABE, K ;

OHNO, N ;

YOSHIOKA, H ;

MABRY, TJ .

CHEMISTRY LETTERS, 1982, (10) :1539-1542

[10]

Pearce C, 1997, ADV APPL MICROBIOL, V44, P1, DOI 10.1016/S0065-2164(08)70459-3

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