A prospective study on bacterial and atypical etiology of acute exacerbation in chronic obstructive pulmonary disease

被引：19

作者：

Nakou, Alexandra ^{[1
,2
]}

Papaparaskevas, Joseph ^{[1
]}

Diamantea, Filia ^{[2
]}

Skarmoutsou, Nikoletta ^{[3
]}

Polychronopoulos, Vlasis ^{[2
]}

Tsakris, Athanassios ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece

[2] Sismanoglio Dist Gen Hosp, Pulm Dept 3, Maroussi 15126, Greece

[3] Sismanoglio Dist Gen Hosp, Dept Microbiol, Maroussi 15126, Greece

来源：

FUTURE MICROBIOLOGY | 2014年 / 9卷 / 11期

关键词：

Chlamydia pneumoniae; culture; exacerbation of COPD; Mycoplasma pneumoniae; PCR; sputum; MYCOPLASMA-PNEUMONIAE INFECTION; CHLAMYDIA-PNEUMONIAE; LUNG-FUNCTION; SYSTEMIC INFLAMMATION; SEROLOGICAL EVIDENCE; CHRONIC-BRONCHITIS; CIGARETTE-SMOKING; COPD; DECLINE; ANTIBODIES;

D O I：

10.2217/FMB.14.90

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Aim: The bacterial and atypical etiology of acute exacerbations of chronic obstructive pulmonary disease was investigated and the diagnostic techniques used were compared among 92 hospitalized patients. Materials & methods: Sputum specimens were investigated using culture and PCR, serological status evaluation was performed and the inflammatory profile was associated with the microbiological results. Results & conclusion: The majority of the patients (65.2%) had very severe airway obstruction. The most common bacteria were Haemophilus influenzae and Pseudomonas aeruginosa (23.9 and 14.1%, respectively). Acinetobacter baumannii- and P. aeruginosa-positive cultures were associated with prolonged hospitalization and severe airway obstruction (p = 0.03 and 0.031, respectively). Chlamydia pneumoniae or Mycoplasma pneumoniae infection was diagnosed in four and two patients, respectively. Discrepant results were detected between PCR and serology, especially regarding C. pneumoniae.

引用

页码：1251 / 1260

页数：10

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