Extended longevity in mice lacking the insulin receptor in adipose tissue

被引：1006

作者：

Blüher, M

Kahn, BB

Kahn, CR

机构：

[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02215 USA

[3] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

来源：

SCIENCE | 2003年 / 299卷 / 5606期

关键词：

D O I：

10.1126/science.1078223

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals. In some organisms, this has been associated with a decreased fat mass and alterations in insulin/insulin-like growth factor 1 (IGF-1) pathways. To further explore these associations with enhanced longevity, we studied mice with a fat-specific insulin receptor knockout (FIRKO). These animals have reduced fat mass and are protected against age-related obesity and its subsequent metabolic abnormalities, although their food intake is normal. Both male and female FIRKO mice were found to have an increase in mean life-span of similar to134 days (18%), with parallel increases in median and maximum life-spans. Thus, a reduction of fat mass without caloric restriction can be associated with increased longevity in mice, possibly through effects on insulin signaling.

引用

收藏

页码：572 / 574

页数：4

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