Long-term potentiation of glutamatergic synaptic transmission induced by activation of presynaptic P2Y receptors in the rat medial habenula nucleus

被引:28
作者
Price, GD
Robertson, SJ
Edwards, FA
机构
[1] UCL, Dept Physiol, London WC1E 6BT, England
[2] Kings Coll London, Acad Dept Neurosurg, London SE5 9PJ, England
关键词
ATP; EPSC; LTP; sleep; uridine nucleotides;
D O I
10.1046/j.1460-9568.2003.02501.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A novel form of long-term potentiation of glutamatergic synaptic transmission is described in the rat medial habenula nucleus. It occurs when uridine 5'-triphosphate is bath applied at low micromolar concentrations and is prevented by Reactive Blue 2, suggesting that it is mediated by P2Y(4) receptors. Uridine 5'-diphosphate can also cause such a Reactive Blue 2-sensitive potentiation, but at higher concentrations (200 mum), suggesting that this might also be an effect on the relatively uridine 5'-diphosphate-insensitive P2Y(4) receptor. The potentiation is due to an increase in presynaptic release probability. It requires neither depolarization nor calcium influx postsynaptically and is thus probably non-Hebbian. When potentiation due to low concentrations of uridine 5'-triphosphate is inhibited in the presence of Reactive Blue 2, uridine 5'-triphosphate causes instead a significant inhibition of glutamate release. We suggest that this inhibition may be mediated by a Reactive Blue 2-insensitive P2Y(2) -like receptor. At higher concentrations of uridine 5'-triphosphate (200 mum), the inhibitory effect dominates such that even in the absence of Reactive Blue 2 no potentiation is seen.
引用
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页码:844 / 850
页数:7
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