Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-γ) gene and risk of prostate cancer among men in a large cancer prevention study

被引：36

作者：

Paltoo, D

Woodson, K

Taylor, P

Albanes, D

Virtamo, J

Tangrea, J

机构：

[1] NCI, Canc Prevent Studies Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[2] NCI, Nutrit Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[3] Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Helsinki, Finland

来源：

CANCER LETTERS | 2003年 / 191卷 / 01期

关键词：

genetic polymorphism; prostate cancer; peroxisome proliferator-activated receptor-gamma; Pro12Ala polymorphism;

D O I：

10.1016/S0304-3835(02)00617-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The nuclear hormone receptor peroxisome proliferator-activated receptor-gamma (PPAR-gamma) may play a role in prostate carcinogenesis. We examined the association between the PPAR-gamma Pro12Ala polymorphism and prostate cancer risk in a cohort of Finnish male smokers. In a nested case-control analysis that included 193 prostate cancer cases and 188 matched controls, we found no significant association between this polymorphism and prostate cancer risk (odds ratio, OR = 1.27, 95% confidence interval, CI: 0.83-1.94), or significant trend or association with tumor stage (OR = 1.28, 95% CI: 0.54-3.04 for metastatic disease) or grade (OR = 1.57, 95% CI: 0.63-3.91 for poorly differentiated disease). The Pro12Ala polymorphism does not appear to play a significant role in prostate cancer risk in this cohort of men. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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页码：67 / 74

页数：8

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