Hints of hidden heritability in GWAS

被引：206

作者：

Gibson, Greg ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Biol, Atlanta, GA 30332 USA

来源：

NATURE GENETICS | 2010年 / 42卷 / 07期

关键词：

MISSING HERITABILITY; COMPLEX DISEASE;

D O I：

10.1038/ng0710-558

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. a related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

引用

页码：558 / 560

页数：4

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