Why do cells release vesicles?

被引：67

作者：

Nieuwland, Rienk ^{[1
]}

Sturk, Augueste ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Lab Expt Clin Chem, Dept Clin Chem, NL-1105 AZ Amsterdam, Netherlands

来源：

THROMBOSIS RESEARCH | 2010年 / 125卷

关键词：

Microparticle; Exosome; Cancer; MEMBRANE-VESICLES; PLATELET MICROPARTICLES; MEDIATED TRANSFER; VIRULENCE GENES; MESSENGER-RNA; CANCER; EXOSOMES; ACTIVATION; MIGRATION; PROTEINS;

D O I：

10.1016/j.thromres.2010.01.037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prokaryotic and eukaryotic cells release vesicles into their environment. To answer the question why eukaryotic cells release vesicles, we may learn from prokaryotes. Bacteria release outer membrane vesicles, resembling microparticles, which act as "multi-purpose carriers". They contain signalling molecules for other bacteria, deliver toxins to host cells and exchange DNA encoding virulence genes between bacteria. Similarly, cell-derived microparticles and exosomes from eukaryotic cells are multi-purpose carriers containing e. g. signalling molecules, cellular waste and functional genetic information. To illustrate our rapidly increasing knowledge on the multiple roles that cellular microparticles and exosomes play in disease progression, we focus on cancer, which is one of the best studied diseases in this aspect. The clinical applications of microparticles and exosomes, including diagnosis, prognosis and therapy, in cancer are discussed. (C) 2010 Elsevier Ltd. All rights reserved.

引用

收藏

页码：S49 / S51

页数：3

相关论文

共 36 条

[1] Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis [J].

Abusamra, AJ ;

Zhong, ZH ;

Zheng, XF ;

Li, M ;

Ichim, TE ;

Chin, JL ;

Min, WP .

BLOOD CELLS MOLECULES AND DISEASES, 2005, 35 (02) :169-173

[2] Intercellular transfer of the oncogenic receptor EGFrvIII by microvesicles derived from tumour cells [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Micallef, Johann ;

Lhotak, Vladimir ;

May, Linda ;

Guha, Abhijit ;

Rak, Janusz .

NATURE CELL BIOLOGY, 2008, 10 (05) :619-U24

[3] Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I [J].

Coleman, ML ;

Sahai, EA ;

Yeo, M ;

Bosch, M ;

Dewar, A ;

Olson, MF .

NATURE CELL BIOLOGY, 2001, 3 (04) :339-345

[4] Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer [J].

Dai, Shengming ;

Wei, Dong ;

Wu, Zhen ;

Zhou, Xiangyang ;

Wei, Xiaomou ;

Huang, Haixin ;

Li, Guisheng .

MOLECULAR THERAPY, 2008, 16 (04) :782-790

[5] Lipid raft-associated protein sorting in exosomes [J].

de Gassart, A ;

Géminard, C ;

Février, B ;

Raposo, G ;

Vidal, M .

BLOOD, 2003, 102 (13) :4336-4344

[6] Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation [J].

del Conde, I ;

Shrimpton, CN ;

Thiagarajan, P ;

López, JA .

BLOOD, 2005, 106 (05) :1604-1611

[7] Endothelial progenitor cell-derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA [J].

Deregibus, Maria Chiara ;

Cantaluppi, Vincenzo ;

Calogero, Raffaele ;

Lo Iacono, Marco ;

Tetta, Ciro ;

Biancone, Luigi ;

Bruno, Stefania ;

Bussolati, Benedetta ;

Camussi, Giovanni .

BLOOD, 2007, 110 (07) :2440-2448

[8] Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent [J].

Diamant, Michaela ;

Tushuizen, Maarten E. ;

Abid-Hussein, Mohammed N. ;

Hau, Chi M. ;

Boing, Anita N. ;

Sturk, Augueste ;

Nieuwland, Rienk .

THROMBOSIS AND HAEMOSTASIS, 2008, 100 (03) :489-497

[9] Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes:: results of thefirst phase I clinical trial [J].

Escudier, B ;

Dorval, T ;

Chaput, N ;

André, F ;

Caby, MP ;

Novault, S ;

Flament, C ;

Leboulaire, C ;

Borg, C ;

Amigorena, S ;

Boccaccio, C ;

Bonnerot, C ;

Dhellin, O ;

Movassagh, M ;

Piperno, S ;

Robert, C ;

Serra, V ;

Valente, N ;

Le Pecq, JB ;

Spatz, A ;

Lantz, O ;

Tursz, T ;

Angevin, E ;

Zitvogel, L .

JOURNAL OF TRANSLATIONAL MEDICINE, 2005, 3 (1)

[10] Porphyromonas gingivalis Outer Membrane Vesicles Enter Human Epithelial Cells via an Endocytic Pathway and Are Sorted to Lysosomal Compartments [J].

Furuta, Nobumichi ;

Tsuda, Kayoko ;

Omori, Hiroko ;

Yoshimori, Tamotsu ;

Yoshimura, Fuminobu ;

Amano, Atsuo .

INFECTION AND IMMUNITY, 2009, 77 (10) :4187-4196

← 1 2 3 4 →