Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury

被引：485

作者：

Angeli, Claudia A. ^{[1
,2
]}

Boakye, Maxwell ^{[2
,3
]}

Morton, Rebekah A. ^{[1
,3
]}

Vogt, Justin ^{[1
,3
]}

Benton, Kristin ^{[1
,3
]}

Chen, Yangshen ^{[2
,3
]}

Ferreira, Christie K. ^{[2
,3
]}

Harkema, Susan J. ^{[1
,2
,3
]}

机构：

[1] Univ Louisville, Frazier Rehabil Inst, Louisville, KY 40202 USA

[2] Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, 220 Abraham Flexner Way,Suite 1509, Louisville, KY 40202 USA

[3] Univ Louisville, Dept Neurosurg, Sch Med, Louisville, KY 40202 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2018年 / 379卷 / 13期

关键词：

EPIDURAL STIMULATION; LOCOMOTION; PATHWAYS; CAT; PARAPLEGIA; DOPA;

D O I：

10.1056/NEJMoa1803588

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Persons with motor complete spinal cord injury, signifying no voluntary movement or sphincter function below the level of injury but including retention of some sensation, do not recover independent walking. We tested intense locomotor treadmill training with weight support and simultaneous spinal cord epidural stimulation in four patients 2.5 to 3.3 years after traumatic spinal injury and after failure to improve with locomotor training alone. Two patients, one with damage to the mid-cervical region and one with damage to the high-thoracic region, achieved over-ground walking (not on a treadmill) after 278 sessions of epidural stimulation and gait training over a period of 85 weeks and 81 sessions over a period of 15 weeks, respectively, and all four achieved independent standing and trunk stability. One patient had a hip fracture during training.

引用

页码：1244 / 1250

页数：7

共 25 条

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Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans [J].