Growth of smooth muscle cell and endothelial cell on PLGA film containing EGCG

被引：2

作者：

Chung, Jin Hyun ^{[1
]}

Lim, Hye Ryun ^{[1
]}

Lee, Tek Hyung ^{[1
]}

Lee, Mi Hee ^{[1
,2
]}

Woo, Yeon I. ^{[1
,2
]}

Baek, Hyun Sook ^{[1
]}

Lee, Seung Jin ^{[3
]}

Kim, Jeong Koo ^{[4
]}

Park, Jong-Chul ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Med Engn, 134 Shinchon-dong, Seoul 120752, South Korea

[2] Yonsei Univ Coll Med, Bk Project Med Sci 21, Seoul 120752, South Korea

[3] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

[4] Inje Univ, Coll Biomed Sci & Engn, Dept Biomed Engn, Kimhae, South Korea

来源：

ASBM7: ADVANCED BIOMATERIALS VII | 2007年 / 342-343卷

关键词：

poly; (D; L-latic-co-glycolic acid); smooth muscle cell; human umbilical vein endothelial cell; epigallocatechin; 3-O-gallate; cell proliferation;

D O I：

10.4028/www.scientific.net/KEM.342-343.93

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly (D,L-latic-co-glycolic acid) (PLGA) has been used as the artificial scaffold for blood vessel formation. In order to hinder smooth muscle cell (SMC) angiogenesis, new scaffold design method of loading Epigallocatechin 3-O-gallate (EGCG) on PLGA film was introduced. PLGA and EGCG were dissolved in acetone and film-shape scaffold was manufactured. Antiangiogenetic effect of EGCG released on scaffold was analyzed for SMC and human umbilical vein endothelial cell (HUVEC) and method for selective inhibition from the difference of growth of SMC and HUVEC was suggested.

引用

页码：93 / +

页数：2

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