Local effect of PACAP and VIP on testicular function in immature and adult rats

被引：22

作者：

Csaba, Z

Csernus, V

Gerendai, I

机构：

[1] Semmelweis Univ Med, Dept Human Morphol & Dev Biol, Neuroendocrine Res Lab, H-1094 Budapest, Hungary

[2] Univ Med, Dept Human Anat, H-7643 Pecs, Hungary

来源：

PEPTIDES | 1997年 / 18卷 / 10期

基金：

匈牙利科学研究基金会;

关键词：

PACAP; VIP; testosterone; testis; hemicastration; intratesticular action;

D O I：

10.1016/S0196-9781(97)00243-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PACAP, VIP, anti PACAP and anti-VIP antisera were injected intratesticularly. In 9-day-old hemicastrated rats PACAP or VIP decreased basal testosterone secretion. In 22-day-old hemicastrates VIP but not PACAP reduced compensatory testicular hypertrophy, however, neither PACAP nor VIP altered steroidogenesis. Anti-VIP antiserum to this age group increased testosterone production and enhanced compensatory testicular hypertrophy. In adult hemicastrates neither the peptides nor the antisera influenced steroidogenesis. Neither in immatures nor in adults treatment of both testes with PACAP or VIP had any effect. Data indicate that both PACAP and VIP might exert a local action on testicular steroidogenesis, on compensatory testicular hypertrophy, and these effects are age-dependent. (C) 1997 Elsevier Science Inc.

引用

页码：1561 / 1567

页数：7

共 38 条

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