Coexistence of Quiescent and Active Adult Stem Cells in Mammals

被引：925

作者：

Li, Linheng ^{[1
,2
]}

Clevers, Hans ^{[3
,4
]}

机构：

[1] SIMR, Kansas City, MO 64110 USA

[2] Univ Kansas, Med Ctr, Dept Pathol, Kansas City, KS 66160 USA

[3] Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[4] Univ Med Ctr, NL-3584 CT Utrecht, Netherlands

来源：

SCIENCE | 2010年 / 327卷 / 5965期

关键词：

HEMATOPOIETIC PROGENITOR CELLS; SELF-RENEWAL; CAENORHABDITIS-ELEGANS; ENDOTHELIAL-CELLS; SMALL-INTESTINE; IN-VIVO; NICHE; PROLIFERATION; ACTIVATION; SKIN;

D O I：

10.1126/science.1180794

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adult stem cells are crucial for physiological tissue renewal and regeneration after injury. Prevailing models assume the existence of a single quiescent population of stem cells residing in a specialized niche of a given tissue. Emerging evidence indicates that both quiescent (out of cell cycle and in a lower metabolic state) and active (in cell cycle and not able to retain DNA labels) stem cell subpopulations may coexist in several tissues, in separate yet adjoining locations. Here, we summarize these findings and propose that quiescent and active stem cell populations have separate but cooperative functional roles.

引用

页码：542 / 545

页数：4

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