Exposure to hexanal odor induces extraordinary Fos expression in the medial preoptic area and amygdala of Fyn tyrosine kinase-deficient mice

被引：3

作者：

Hamaguchi-Hamada, K

Hamada, S

Yagi, T

机构：

[1] Osaka Univ, KOKORO Biol Grp, Labs Integrated Biol, Grad Sch Frontier Biosci, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Forntier Biosci, KOKORO Biol Grp, Labs Integrated Biol, Suita, Osaka 5650871, Japan

[3] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Tokyo 1500002, Japan

[4] Natl Inst Physiol Sci, Lab Neurobiol & Behav Genet, Myodaiji, Okayama 4448585, Japan

来源：

MOLECULAR BRAIN RESEARCH | 2004年 / 130卷 / 1-2期

基金：

日本科学技术振兴机构;

关键词：

Fyn tyrosine kinase; maternal behavior; medial preoptic area; amygdala; hexanal; Fos;

D O I：

10.1016/j.molbrainres.2004.07.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Our previous study revealed that the odor of hexanal, which is derived from the wood chips used as bedding, influenced mouse maternal behavior and induced the neonatal death of Fyn-deficient (fyn(-/-)) pups bom of fyn(-/-) parents. To clarify what regions of the brain aye involved in this effect, we examined which brain regions of fyn(-/-) and Fyn-heterozygous (fyn(+/-)) females were activated by hexanal odor using Fos immunohistochemistry. Hexanal induced Fos immumoreactivity in the primary olfactory cortex and in the medial and central arrygdala of both jyn(+/-) and fyn(-/-) mice. In fyn(-/-) females, hexanal also induced the activation of the medial preoptic area and the basolateral and posteriontedial cortical amygdala, which are known to be involved in the control of maternal and emotional behavior. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：187 / 190

页数：4

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