Fibrocytes in health and disease

被引：180

作者：

Herzog, Erica L. ^{[1
]}

Bucala, Richard ^{[2
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Sect Pulm & Crit Care Med, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Rheumatol Sect, New Haven, CT 06520 USA

来源：

EXPERIMENTAL HEMATOLOGY | 2010年 / 38卷 / 07期

关键词：

PERIPHERAL-BLOOD FIBROCYTES; MARROW-DERIVED CELLS; CIRCULATING FIBROCYTES; T-CELLS; PULMONARY-FIBROSIS; RENAL FIBROSIS; ADHERENT CELLS; BURN PATIENTS; IN-VITRO; BONE;

D O I：

10.1016/j.exphem.2010.03.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibrocytes are circulating mesenchymal progenitor cells that participate in tissue responses to injury and invasion. Accumulating knowledge from animal models regarding the differentiation, trafficking, and function of these cells implicates them in the development of diseases characterized by chronic inflammation and excessive collagen deposition. Recent data obtained from the clinical setting suggests that the enumeration of circulating fibrocytes may be a biomarker for disease progression in chronic lung diseases including asthma and pulmonary fibrosis. A greater understanding of the immunologic mediators that influence fibrocyte biology suggests new opportunities for therapeutic manipulation of these cells in fibrogenesis. This review integrates new developments in the cellular and molecular biology of fibrocytes with current concepts regarding the etiopathogenesis of fibrosing disorders. (C) 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc.

引用

页码：548 / 556

页数：9

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