HLA class II genotypes in Mexican Mestizos with familial sand nonfamilial multiple sclerosis

被引：36

作者：

Alvarado-de la Barrera, C

Zúñiga-Ramos, J

Ruíz-Morales, JA

Estañol, B

Granados, J

Llorente, L

机构：

[1] Inst Nacl Nutr Salvador Zubiran, Dept Inmunol & Reumatol, Mexico City, DF, Mexico

[2] Inst Nacl Nutr Salvador Zubiran, Dept Neurol, Mexico City, DF, Mexico

来源：

NEUROLOGY | 2000年 / 55卷 / 12期

关键词：

D O I：

10.1212/WNL.55.12.1897

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Predisposition to MS is associated with the HLA-DR2 antigen in white patients. The authors investigated the genetic factors behind the increasing frequency of MS in the Mexican population. HLA-DR and DQ were analyzed in 17 patients with MS, 15 of their first-degree relatives, and 99 healthy ethnically matched controls. DR2 or DR3 was found in 15 of 17 patients. In controls, both alleles had frequencies less than 0.05. MS in Mexican patients was associated with HLA-DR2 and DR3.

引用

页码：1897 / 1900

页数：4

共 10 条

[1]

BURGOSVARGAS R, 1990, SPINE STATE ART REV

[2]

CHARRON D, 1997, P 12 INT HIST WORKSH

[3] A POPULATION-BASED STUDY OF MULTIPLE-SCLEROSIS IN TWINS [J].