Genetic and epigenetic regulators of pluripotency

被引：503

作者：

Surani, M. Azim ^{[1
]}

Hayashi, Katsuhiko ^{[1
]}

Hajkova, Petra ^{[1
]}

机构：

[1] Univ Cambridge, Wellcome Trust Canc Res UK, Gurdon Inst, Cambridge CB2 1QN, England

来源：

CELL | 2007年 / 128卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/j.cell.2007.02.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic and epigenetic mechanisms regulate the transition from the totipotent zygote to pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts. These pluripotent cells can be propagated indefinitely in vitro, underpinned by a unique epigenetic state. Following implantation of the blastocyst, diverse epigenetic modifiers control differentiation of pluripotent epiblast cells into somatic cells, while specification of germ cells requires repression of the somatic program. Regenerating totipotency during development of germ cells entails re-expression of pluripotency-specific genes and extensive erasure of epigenetic modifications. Increasing knowledge of key underlying mechanisms heightens prospects for creating pluripotent cells directly from adult somatic cells. © 2007 Elsevier Inc. All rights reserved.

引用

页码：747 / 762

页数：16

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