Isolation of 1-methylherbipoline salts of halisulfate-1 and of suvanine as serine protease inhibitors from a marine sponge, Coscinoderma mathewsi

被引：38

作者：

Kimura, J

Ishizuka, E

Nakao, Y

Yoshida, WY

Scheuer, PJ

Kelly-Borges, M

机构：

[1] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA

[2] Aoyama Gakuin Univ, Coll Sci & Engn, Dept Chem, Tokyo 157, Japan

[3] Nat Hist Museum, London SW7 2BD, England

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 02期

关键词：

D O I：

10.1021/np970376z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided isolation of serine protease inhibitors from a marine sponge, Coscinoderma mathewsi, has yielded 1-methylherbipoline salts of halisulfate-1 and of suvanine. Structures of these compounds were identified by spectroscopic analyses and literature data. Antithrombin and antitrypsin activity was determined.

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页码：248 / 250

页数：3

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