Streptococcus pneumoniae: virulence factors and variation

被引：218

作者：

Mitchell, A. M. ^{[1
]}

Mitchell, T. J. ^{[1
]}

机构：

[1] Univ Glasgow, Glasgow Biomed Res Ctr, Div Infect & Immun, Fac Biomed & Life Sci, Glasgow G12 8TA, Lanark, Scotland

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2010年 / 16卷 / 05期

关键词：

Disease; genome; infection; pneumococcus; review; virulence; PNEUMOCOCCAL SURFACE PROTEIN; INHIBIT COMPLEMENT DEPOSITION; PNEUMOLYSIN-NEGATIVE MUTANT; IL-17-PRODUCING T-CELLS; BINDING PROTEIN; GENOMIC ANALYSIS; NONHEMOLYTIC PNEUMOLYSIN; CAPSULAR POLYSACCHARIDE; EXTRACELLULAR-MATRIX; BIOFILM FORMATION;

D O I：

10.1111/j.1469-0691.2010.03183.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

P>Streptococcus pneumoniae is a major pathogen of humans, causing diseases such as pneumonia and meningitis. The organism produces several virulence factors that are involved in the disease process. The molecular basis of the action of some of these virulence factors is being elucidated. The advent of whole genome sequencing combined with biological studies has demonstrated that genome variation is important in the ability of pneumococci to interact with the host. This review discusses the biological activity of several pneumococcal virulence factors, and describes how genome variation may impact on the ability of pneumococci to cause disease.

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页码：411 / 418

页数：8

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