Optical imaging of dynamic horizontal spread of excitation in rat auditory cortex slices

被引：22

作者：

Kubota, M ^{[1
]}

Sugimoto, S ^{[1
]}

Horikawa, J ^{[1
]}

Nasu, M ^{[1
]}

Taniguchi, I ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Med Res Inst, Dept Neurophysiol, Tokyo 101, Japan

来源：

NEUROSCIENCE LETTERS | 1997年 / 237卷 / 2-3期

关键词：

optical imaging; auditory cortex; spatiotemporal pattern; horizontal propagation; voltage-sensitive dye; glutamate receptors; slice preparation;

D O I：

10.1016/S0304-3940(97)00806-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Optical recordings using a voltage-sensitive dye (RH482) were conducted in brain slice preparations to investigate spatiotemporal patterns of excitation in the rat auditory cortex. Electrical stimulation of the border between the white matter and layer VI evoked vertical as well as horizontal spreading responses. While Velocities of vertical and horizontal propagation of excitation were similar to those reported in non-disinhibited preparations, the horizontal propagation was widespread and strong especially in layers II/III in auditory cortex slices. This horizontal spread was blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) but not by D-2-amino-5-phosphonopentanoic acid (D-AP5). These results suggest that the horizontal responses, especially in layers II/III, are prominent and are mediated primarily by non-N-methyl-D-aspartic acid (NMDA) receptors in the auditory cortex. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：77 / 80

页数：4

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