Combinatorial synthesis of dihydropyridone libraries and their derivatives

被引：97

作者：

Creswell, MW ^{[1
]}

Bolton, GL ^{[1
]}

Hodges, JC ^{[1
]}

Meppen, M ^{[1
]}

机构：

[1] Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 16期

关键词：

D O I：

10.1016/S0040-4020(98)00130-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polymer-supported quench methodology has been used for parallel purification of combinatorial libraries of dihydropyridones and their derivatives. The dihydropyridone scaffold was assembled via a solution phase Lewis acid catalyzed, hetero-Diels-Alder reaction. Further modifications allow for the rapid generation of subsequent aminopiperidine and acyl-aminopiperidine libraries utilizing a library from library approach. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3983 / 3998

页数：16

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