Supercritical antisolvent micronization of Cefonicid: thermodynamic interpretation of results

被引：72

作者：

Reverchon, E ^{[1
]}

De Marco, L ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Ingn Chim & Alimetare, I-84084 Fisciano, SA, Italy

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2004年 / 31卷 / 02期

关键词：

supercritical antisolvent; Cefonicid; vapor-liquid equilibria; micronization;

D O I：

10.1016/j.supflu.2003.11.002

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this work, the micronization of Cefonicid (a Cephalosporinic antibiotic) from Dimethylsulfoxide (DMSO) has been successfully performed using the supercritical antisolvent (SAS) precipitation. We obtained sub-microparticles or empty shells of Cefonicid ranging from about 0.2 mum to more than 50 mum simply varying the concentration in the liquid solution and/or the process temperature. The analysis of the morphologies observed has been supported by thermodynamic arguments; in particular, we tried to relate the different morphologies obtained to the position of the process operating point with respect to the mixture critical point (MCP) on the binary system and tried to describe the kind of vapor-liquid equilibria (VLE) modifications induced by the presence of Cefonicid. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：207 / 215

页数：9

共 24 条

[1] NON-AQUEOUS TERNARY MIXTURES WITH ISLAND MISCIBILITY GAPS [J].

BECKER, F ;

RICHTER, P .

FLUID PHASE EQUILIBRIA, 1989, 49 :157-166

[2]

Benedetti L, 1997, BIOTECHNOL BIOENG, V53, P232, DOI 10.1002/(SICI)1097-0290(19970120)53:2<232::AID-BIT15>3.0.CO

[3]

2-M

[4] POLYMERIC MICROSPHERES PREPARED BY SPRAYING INTO COMPRESSED CARBON-DIOXIDE [J].

BODMEIER, R ;

WANG, H ;

DIXON, DJ ;

MAWSON, S ;

JOHNSTON, KP .

PHARMACEUTICAL RESEARCH, 1995, 12 (08) :1211-1217

[5] The building-up of phase diagrams [J].

Calado, JCG ;

Lopes, JNC .

PURE AND APPLIED CHEMISTRY, 1999, 71 (07) :1183-1196

[6] POLYMERIC MATERIALS FORMED BY PRECIPITATION WITH A COMPRESSED FLUID ANTISOLVENT [J].

DIXON, DJ ;

JOHNSTON, KP ;

BODMEIER, RA .

AICHE JOURNAL, 1993, 39 (01) :127-139

[7] GAS ANTISOLVENT RECRYSTALLIZATION OF RDX - FORMATION OF ULTRA-FINE PARTICLES OF A DIFFICULT-TO-COMMINUTE EXPLOSIVE [J].

GALLAGHER, PM ;

COFFEY, MP ;

KRUKONIS, VJ ;

HILLSTROM, WW .

JOURNAL OF SUPERCRITICAL FLUIDS, 1992, 5 (02) :130-142

[8] Fine particles preparation of Red Lake C Pigment by supercritical fluid [J].

Gao, Y ;

Mulenda, TK ;

Shi, YF ;

Yuan, WK .

JOURNAL OF SUPERCRITICAL FLUIDS, 1998, 13 (1-3) :369-374

[9] Amorphous vanadium phosphate catalysts prepared using precipitation with supercritical CO2 as an antisolvent [J].

Hutchings, GJ ;

Lopez-Sanchez, JA ;

Bartley, JK ;

Webster, JM ;

Burrows, A ;

Kiely, CJ ;

Carley, AF ;

Rhodes, C ;

Hävecker, M ;

Knop-Gericke, A ;

Mayer, RW ;

Schlögl, R ;

Volta, JC ;

Poliakoff, M .

JOURNAL OF CATALYSIS, 2002, 208 (01) :197-210

[10] Particle design using supercritical fluids: Literature and patent survey [J].

Jung, J ;

Perrut, M .

JOURNAL OF SUPERCRITICAL FLUIDS, 2001, 20 (03) :179-219

← 1 2 3 →