Identification of synergistic signals initiating inner ear development

被引:212
作者
Ladher, RK
Anakwe, KU
Gurney, AL
Schoenwolf, GC
Francis-West, PH [1 ]
机构
[1] Kings Coll, Dept Craniofacial Dev, London SE1 9RT, England
[2] Genentech Inc, Dept Mol Biol, San Francisco, CA USA
[3] Univ Utah, Dept Neurobiol & Anat, Salt Lake City, UT 84132 USA
关键词
D O I
10.1126/science.290.5498.1965
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Tissue manipulation experiments in amphibians more than 50 years ago showed that induction of the inner ear requires two signals: a mesodermal signal followed by a neural signal. However, the molecules mediating this process have remained elusive. We present evidence for mesodermal initiation of otic development in higher Vertebrates and show that the mesoderm can direct terminal differentiation of the inner ear in rostral ectoderm. Furthermore, we demonstrate the synergistic interactions of the extracellular polypeptide ligands FGF-19 and Wnt-8c as mediators of mesodermal and neural signals, respectively, initiating inner ear development.
引用
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页码:1965 / 1967
页数:3
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