The many ways of Wnt in cancer

被引：727

作者：

Polakis, Paul ^{[1
]}

机构：

[1] Genentech Inc, Dept Res, San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2007年 / 17卷 / 01期

关键词：

D O I：

10.1016/j.gde.2006.12.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

More than 20 years ago, the oncogenicity of a Writ ligand was revealed in a series of experiments originating with random proviral integration in mice. The significance of Writ signaling in human cancer has since been buttressed by the identification of mutations in genes coding for the Writ pathway components Axin, APC, and beta-catenin. This review summarizes the reported genetic defects in the Writ pathway, with an emphasis on their functional contribution to human tumor progression.

引用

页码：45 / 51

页数：7

共 66 条

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