We perform a joint inversion of Quaternary strain rates and 238 Global Positioning Syst;em (GPS) velocities in Asia fur a self-consistent velocity field. The reference frames for all geodetic velocity observations are determined in our inversion procedure, India (IN) moves relative to Eurasia (EU) about a pole of rotation at (29.78 degrees N, 7.51 degrees E;, 0.353 degrees Myr(-1)), which yields a velocity along the Himalaya within India that is similar to 73-76% of the magnitude of the IN-EU NUVEL-1A velocity and a vector azimuth that is 8-10 degrees clockwise of NUVEL-1A IN-EU vector azimuth. Relative to Eurasia, south China moves at 9-11 mm/yr in the direction 110-120 degrees with a pole position (64.84 degrees N, 156.74 degrees E, 0.12 degrees Myr(-1)). Amurian block motion has a pole position iri a similar location but at a slower rate (64.61 degrees N, 158.23 degrees E, 0.077 degrees Myr(-1)) and most of the Amurian-Eurasia motion is accommodated by extension across Lake Baikal. Tarim Basin moves relative to Eurasia about a pole of rotation at (39.24 degrees N, 98.2 degrees E, -0.539 degrees Myr(-1)) and similar to 16-18 mm/yr of shortening is accommodated across the west central Tien Shan. There is distributed E-W extension throughout both southern and north central Tibet. Within southern Tibet, between the longitudes of 77 degrees E to 92 degrees E, the deformation field accommodates similar to 16-19 mm/yr of E-W extension. We compare predicted seismic moment rates with those observed in this century iu Asia. Total observed seismic moment rates wit,hin the entire area of central and east Asia (2.2 x 10(7) km(2)) in this century are 2.26 +/- 0.7 x 10(20) N m yr(-1) as compared with a predicted total rate of 2.03 +/- 0.066 x 10(20) N m yr(-1). Comparisons between observed and predicted moment rates within 42 subregions reflect the generally unstable process of inferring long-term seismic moment rates from a catalog of limited duration (94 years), All observation period of similar to 10,000 years would be required to reduce uncertainties in observed. seismic: moment rate tu the same sire as the uncertainties in model tectonic moment, rates, inferred from the joint inversion of GPS and Quaternary rates of strain. We show that in general, a better correlation with model tectonic: moment rate is inferred from the: seismicity catalog by considering the numbers of earthquakes above a cutoff magnitude (m(b) > 5.0: for the period January 1, 1965, to January 1, 1999).