Role of neutralizing antibodies in PRRSV protective immunity

被引：303

作者：

Lopez, OJ ^{[1
]}

Osorio, FA ^{[1
]}

机构：

[1] Univ Nebraska, Dept Vet & Biomed Sci, Lincoln, NE 68583 USA

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2004年 / 102卷 / 03期

关键词：

D O I：

10.1016/j.vetimm.2004.09.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Little has been known about the components of the immune system that are effective in the protection of a pig against PRRSV infection. Although antibodies were initially perceived as a deleterious, ineffective component of the PRRSV-specific immune response, neutralizing antibodies (NA) are now considered to be an important correlate of protective immunity against PRRSV. This paper reviews the current knowledge on arterivirus-specific NA, the role that NA have in protection against infection with PRRSV, as well as the viral molecular structures that are responsible for the production of this type of antibodies by the pig. This information should prove central to the design of new generation vaccines against PRRSV. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：155 / 163

页数：9

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