Obesity and nonalcoholic fatty liver disease

被引：102

作者：

Angulo, Paul ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Miles & Shirley Fiterman Ctr Digest Dis, Rochester, MN 55905 USA

来源：

NUTRITION REVIEWS | 2007年 / 65卷 / 06期

关键词：

diabetes; dyslipidemia; insulin resistance; nonalcoholic fatty liver disease (NAFLD); obesity;

D O I：

10.1301/nr.2007.jun.S57-S63

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

With the increasing prevalence of obesity and type 2 diabetes mellitus in the general population, nonalcoholic fatty liver disease (NAFLD) has become a common diagnosis in clinical practice. Insulin resistance and oxidative stress play an important role in NAFLD development and progression. NAFLD affects one in three adults and one in 10 children/adolescents in the United States. Mortality in patients with NAFLD is significantly higher than in the general population of same age and gender with liver-related complications. Lifestyle intervention may improve NAFLD, but medications that increase insulin sensitivity and the antioxidant defenses in the liver deserve evaluation in carefully controlled trials.

引用

收藏

页码：S57 / S63

页数：7

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