Sequence analysis demonstrates that VP6, NSP1 and NSP4 genes of Indian neonatal rotavirus strain 116E are of human origin

被引:14
作者
Cunliffe, NA
Das, BK
Ramachandran, M
Bhan, MK
Glass, RI
Gentsch, JR
机构
[1] UNIV LIVERPOOL,DEPT MED MICROBIOL & GENITOURINARY MED,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND
[2] UNIV LIVERPOOL,WELLCOME TRUST LIVERPOOL CTR CLIN TROP MED,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND
[3] ALL INDIA INST MED SCI,DEPT MICROBIOL,NEW DELHI 110029,INDIA
[4] ALL INDIA INST MED SCI,DEPT PEDIAT,NEW DELHI 110029,INDIA
基金
英国惠康基金;
关键词
rotavirus; neonate; 116E; nucleotide sequence; vaccine;
D O I
10.1023/A:1007958914141
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We have sequenced the genes encoding the inner capsid protein VP6 and the nonstructural proteins NSP1 and NSP4 of the Indian neonatal serotype P8[11]G9 human/bovine reassortant candidate vaccine rotavirus strain 116E, These three genes share a high degree of sequence and deduced amino acid homology with human prototype strain Wa. Our results confirm and extend those of previous RNA-RNA hybridization studies which suggested that these genes are of human origin, and will facilitate examination of the host immune response to 116E induced by natural infection and vaccination.
引用
收藏
页码:39 / 44
页数:6
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