Iridoid and megastigmane glycosides from Phlomis aurea

From the leaves of Phlomis aurea, two new iridoids of unique structures named 3-epiphlomurin (1) and phlomurin (2), a new megastigmane glucoside phlomuroside (3) and a new benzyl alcohol glycoside having the structure benzyl alcohol-O-beta -xylopyranosyl-(1-->2)-beta -glucopyranoside (4) have been isolated together with four known iridoids auroside, lamiide, 8-epiloganin and iporamiide, two known phenolic glycosides acteoside (verbascoside) and syringin, one known phenylethanoid glycoside 2-phenylethyl-O-beta -xylopyranosyl-(1-->2)-beta -glucopyranoside, one known lignan liriodendrin and three known flavonoids chrysaeriol-7-O-beta -glucopyranoside, acacetin-7-O-beta -glucopyranoside and luteolin-7-O-beta -glucopyranoside. The structures of the isolated compounds were verified by means of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectral analyses. (C) 2000 Elsevier Science Ltd. All rights reserved.