Insights from in vivo modification of adrenergic receptor gene expression

被引:56
作者
Rohrer, DK [1 ]
Kobilka, BK
机构
[1] Stanford Univ, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA
[2] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA
关键词
transgenic; knockout; pharmacology; physiology; subtype;
D O I
10.1146/annurev.pharmtox.38.1.351
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Adrenergic receptors are key targets within the autonomic nervous system, regulating a wide variety of physiological processes. The ability to modify adrenergic receptor expression patterns in vivo has added a powerful new tool to the functional analysis of these receptors. Modification of adrenergic receptor gene expression by overexpression, genetic ablation, or site-specific mutation has added new insight to models of receptor coupling behavior, pharmacology, and subtype-specific physiological function. This review highlights some of the recent advances resulting from such genetic approaches to the study of adrenergic receptors.
引用
收藏
页码:351 / 373
页数:23
相关论文
共 103 条
  • [1] Transgenic mice with cardiac overexpression of alpha(1B)-adrenergic receptors - In vivo alpha(1)-adrenergic receptor-mediated regulation of beta-adrenergic signaling
    Akhter, SA
    Milano, CA
    Shotwell, KF
    Cho, MC
    Rockman, HA
    Lefkowitz, RJ
    Koch, WJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (34) : 21253 - 21259
  • [2] Transgenic mice carrying the human beta(2)-adrenergic receptor gene with its own promoter overexpress beta(2)-adrenergic receptors in liver
    Andre, C
    Erraji, L
    Gaston, J
    Grimber, G
    Briand, P
    Guillet, JG
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 241 (02): : 417 - 424
  • [3] ATYPICAL BETA-ADRENOCEPTOR ON BROWN ADIPOCYTES AS TARGET FOR ANTI-OBESITY DRUGS
    ARCH, JRS
    AINSWORTH, AT
    CAWTHORNE, MA
    PIERCY, V
    SENNITT, MV
    THODY, VE
    WILSON, C
    WILSON, S
    [J]. NATURE, 1984, 309 (5964) : 163 - 165
  • [4] SPECIFIC ATRIAL OVEREXPRESSION OF G-PROTEIN COUPLED HUMAN BETA(1)-ADRENOCEPTORS IN TRANSGENIC MICE
    BERTIN, B
    MANSIER, P
    MAKEH, I
    BRIAND, P
    ROSTENE, W
    SWYNGHEDAUW, B
    STROSBERG, AD
    [J]. CARDIOVASCULAR RESEARCH, 1993, 27 (09) : 1606 - 1612
  • [5] (+)-NIGULDIPINE BINDS WITH VERY HIGH-AFFINITY TO CA-2+ CHANNELS AND TO A SUBTYPE OF ALPHA-1-ADRENOCEPTORS
    BOER, R
    GRASSEGGER, A
    SCHUDT, C
    GLOSSMANN, H
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1989, 172 (02): : 131 - 145
  • [6] PHYSIOLOGICAL-EFFECTS OF INVERSE AGONISTS IN TRANSGENIC MICE WITH MYOCARDIAL OVEREXPRESSION OF THE BETA(2)-ADRENOCEPTOR
    BOND, RA
    LEFF, P
    JOHNSON, TD
    MILANO, CA
    ROCKMAN, HA
    MCMINN, TR
    APPARSUNDARAM, S
    HYEK, MF
    KENAKIN, TP
    ALLEN, LF
    LEFKOWITZ, RJ
    [J]. NATURE, 1995, 374 (6519) : 272 - 276
  • [7] AGONIST AND ANTAGONIST CHARACTERIZATION OF A PUTATIVE ADRENOCEPTOR WITH DISTINCT PHARMACOLOGICAL PROPERTIES FROM THE ALPHA-SUBTYPES AND BETA-SUBTYPES
    BOND, RA
    CLARKE, DE
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 (03) : 723 - 734
  • [8] BRODDE, 1991, PHARMACOL REV, V43, P350
  • [9] BRODDE OE, 1991, PHARMACOL REV, V43, P203
  • [10] VASCULAR ALPHA-ADRENOCEPTORS - FROM THE GENE TO THE HUMAN
    BYLUND, DB
    REGAN, JW
    FABER, JE
    HIEBLE, JP
    TRIGGLE, CR
    RUFFOLO, RR
    [J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1995, 73 (05) : 533 - 543