Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra

被引：103

作者：

Smidt, MP ^{[1
]}

Smits, SM ^{[1
]}

Burbach, JPH ^{[1
]}

机构：

[1] Univ Utrecht, Dept Pharmacol & Anat, Rudolf Magnus Inst Neurosci, NL-3584 CG Utrecht, Netherlands

来源：

CELL AND TISSUE RESEARCH | 2004年 / 318卷 / 01期

关键词：

embryonic development; midbrain; aphakia mouse mutant; striatal connectivity; behavior;

D O I：

10.1007/s00441-004-0943-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The homeobox gene Pitx3 plays an important part in the development and function of vertebrate midbrain dopaminergic neurons. Re-localization of the genetic defect in the mouse mutant aphakia to the Pitx3 locus, together with the subsequent identification of two deletions causing the gene to be silent, has been the hallmark of several studies into the role of Pitx3. In this review, we summarize the data and reflect on the role of Pitx3 in the development of dopamine neurons in the midbrain. The data indicate that Pitx3 is essential for the survival of dopamine neurons located in the substantia nigra compacta during development. Molecular analysis of the underlying mechanisms might provide new insights for understanding the selective degeneration observed in Parkinson patients.

引用

页码：35 / 43

页数：9

共 59 条

[1] Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease [J].

Barzilai, A ;

Melamed, E .

TRENDS IN MOLECULAR MEDICINE, 2003, 9 (03) :126-132

[2]

Burbach JPH, 2003, ANN NY ACAD SCI, V991, P61

[3] A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter [J].

Cazorla, P ;

Smidt, MP ;

O'Malley, KL ;

Burbach, JPH .

JOURNAL OF NEUROCHEMISTRY, 2000, 74 (05) :1829-1837

[4]

Chen HX, 1998, DEV GENET, V22, P314, DOI 10.1002/(SICI)1520-6408(1998)22:4<314::AID-DVG2>3.0.CO

[5]

2-9

[6] CLIMBING BEHAVIOR INDUCED BY APOMORPHINE IN MICE - POTENTIAL MODEL FOR DETECTION OF NEUROLEPTIC ACTIVITY [J].

COSTALL, B ;

NAYLOR, RJ ;

NOHRIA, V .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 50 (01) :39-50

[7] Effect of cocaine, nomifensine, GBR 12909 and WIN 35428 on carbon fiber microelectrode sensitivity for voltammetric recording of dopamine [J].

Davidson, C ;

Ellinwood, EH ;

Douglas, SB ;

Lee, TH .

JOURNAL OF NEUROSCIENCE METHODS, 2000, 101 (01) :75-83

[8] Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome [J].

Dreyer, SD ;

Zhou, G ;

Baldini, A ;

Winterpacht, A ;

Zabel, B ;

Cole, W ;

Johnson, RL ;

Lee, B .

NATURE GENETICS, 1998, 19 (01) :47-50

[9] Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation [J].

Gage, PJ ;

Camper, SA .

HUMAN MOLECULAR GENETICS, 1997, 6 (03) :457-464

[10] Cataract mutations and lens development [J].

Graw, J .

PROGRESS IN RETINAL AND EYE RESEARCH, 1999, 18 (02) :235-267

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