Decreased inhibition by leptin of hypothalamic arcuate neurons in neonatally overfed young rats

被引：90

作者：

Davidowa, H

Plagemann, A

机构：

[1] Humboldt Univ, Fac Med Charite, Johannes Mueller Inst Physiol, D-10117 Berlin, Germany

[2] Humboldt Univ, Fac Med Charite, Inst Expt Endocrinol, D-10117 Berlin, Germany

来源：

NEUROREPORT | 2000年 / 11卷 / 12期

关键词：

brain slice; hypothalamus physiology; leptin; overweight; postnatal overnutrition; single unit activity;

D O I：

10.1097/00001756-200008210-00037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats neonatally overnourished due to a reduced litter size develop persisting overweight throughout life. A presumed mechanism leading to this 'malprogramming' consists of an acquired change of the responsiveness to leptin of the neuronal system regulating feeding behavior. The study reports significant differences in the effects of leptin on single unit activity of the arcuate nucleus in brain slices of normal compared with early postnatally overfed juvenile rats. The firing rate of arcuate neurons in normal rats was inhibited by leptin (Wilcoxon test p < 0.0001 n = 42), whereas it was not changed in obese rats (Wt p = 2.4, n = 35). The reduced inhibition by leptin of arcuate neurons in neonatally overfed rats might indicate an acquired hypothalamic leptin resistance contributing to persistent hyperphagia and overweight. NeuroReport 11:2795-2798 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：2795 / 2798

页数：4

共 23 条

[1] Leptin enters the brain by a saturable system independent of insulin
Banks, WA
Kastin, AJ
Huang, WT
Jaspan, JB
Maness, LM
[J]. PEPTIDES, 1996, 17 (02) : 305 - 311
[2] The causes of obesity: Advances in molecular biology but stagnation on the genetic front
Bouchard, C
[J]. DIABETOLOGIA, 1996, 39 (12) : 1532 - 1533
[3] Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
Chen, H
Charlat, O
Tartaglia, LA
Woolf, EA
Weng, X
Ellis, SJ
Lakey, ND
Culpepper, J
Moore, KJ
Breitbart, RE
Duyk, GM
Tepper, RI
Morgenstern, JP
[J]. CELL, 1996, 84 (03) : 491 - 495
[4] CRITICAL PERIODS IN CHILDHOOD FOR THE DEVELOPMENT OF OBESITY
DIETZ, WH
[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1994, 59 (05) : 955 - 959
[5] PERINATAL HYPERINSULINISM AS POSSIBLE PREDISPOSING FACTOR FOR DIABETES-MELLITUS, OBESITY AND ENHANCED CARDIOVASCULAR RISK IN LATER LIFE
DORNER, G
PLAGEMANN, A
[J]. HORMONE AND METABOLIC RESEARCH, 1994, 26 (05) : 213 - 221
[6] Leptin activates neurons in ventrobasal hypothalamus and brainstem
Elmquist, JK
Ahima, RS
MaratosFlier, E
Flier, JS
Safer, CB
[J]. ENDOCRINOLOGY, 1997, 138 (02) : 839 - 842
[7] The effect of leptin on feeding-regulating neurons in the rat hypothalamus
Funahashi, H
Yada, T
Muroya, S
Takigawa, M
Ryushi, T
Horie, S
Nakai, Y
Shioda, S
[J]. NEUROSCIENCE LETTERS, 1999, 264 (1-3) : 117 - 120
[8] Glaum SR, 1996, MOL PHARMACOL, V50, P230
[9] Håkansson ML, 1998, J NEUROSCI, V18, P559
[10] Increased response to NPY of hypothalamic VMN neurons in postnatally overfed juvenile rats
Heidel, E
Plagemann, A
Davidowa, H
[J]. NEUROREPORT, 1999, 10 (09) : 1827 - 1831

← 1 2 3 →