Synthesis of 5-methoxylated 3-pyrrolin-2-ones via the rearrangement of chlorinated pyrrolidin-2-ones

被引：35

作者：

Ghelfi, F

Stevens, CV

Laureyn, I

Van Meenen, E

Rogge, TM

De Buyck, L

Nikitin, KV

Grandi, R

Libertini, E

Pagnoni, UM

Schenetti, L

机构：

[1] Univ Ghent, Fac Agr & Appl Biol Sci, Dept Organ Chem, B-9000 Ghent, Belgium

[2] Univ Modena & Reggio Emilia, Dipartimento Chim, I-41100 Modena, Italy

[3] Natl Univ Ireland Univ Coll Dublin, Dept Chem, Dublin 4, Ireland

来源：

TETRAHEDRON | 2003年 / 59卷 / 08期

关键词：

pyrrolidinones; pyrrolinones; lactams; eliminations;

D O I：

10.1016/S0040-4020(03)00044-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of N-substituted 4-methyl-2-pyrrolidinones or 4-diethoxyphosphoryl analogues, carrying at least two chlorine atoms between the C(3) and C(6) carbons, with alkaline methoxide in methanol afforded the corresponding 5-methoxylated 3-pyrrolin-2-ones, useful adducts for the preparation of agrochemicals or medicinal compounds. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1147 / 1157

页数：11

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