Infections as a major preventable cause of human cancer

被引：560

作者：

Kuper, H

Adami, HO

Trichopoulos, D

机构：

[1] Karolinska Inst, Dept Med Epidemiol, S-17177 Stockholm, Sweden

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

来源：

JOURNAL OF INTERNAL MEDICINE | 2000年 / 248卷 / 03期

关键词：

aetiology; cancer; infections; public health;

D O I：

10.1046/j.1365-2796.2000.00742.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Infections may be responsible for over 15% of all malignancies worldwide. Important mechanisms by which infectious agents may induce carcinogenesis include the production of chronic inflammation. the transformation of cells by insertion of oncogenes and inhibition of tumour suppressors, and the induction of immunosuppression. Common characteristics shared by infectious agents linked to malignancies are that they are persistent in the host, often highly prevalent in the host population and induce cancer after a long latency. The associations between a selection of infectious agents and malignancies are covered in detail.

引用

页码：171 / 183

页数：13

共 112 条

[1] The prevalence of hepatitis C virus infection in the United States, 1988 through 1994 [J].